Abstract

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF CRINUM LATIFOLIUM EXTRACT ON EXPERIMENTAL ANIMALS

Dr. DV Kishore*, Shabana Begum, Dr. Shaik Mohd Khasim, Dr. Sridhar Baburao

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Abstract

Depression is among the most widespread critical conditions that requires immediate attention. However, numerous depressive episodes remain unnoticed. Patients with depression had a higher level of cognitive impairment than people with chronic health conditions including hypertension, diabetes, arthritis, or coronary artery disease.The depression may be caused by a decreased levels or dysfunctioning of monoaminergic transmitters, serotonin (5-HT), norepinephrine (NE), and dopamine (DA). In the present study the evaluation of antidepressant activity of Crinum latifolium on experimental animals is carried out. Mice were treated with methanolic extract of C. latifolium (MECL) at a doses (200mg/kg and 400mg/kg) and Imipramine (15mg/kg) as standard drug and signs of behavioral, neurological toxicity, and mortality were observed. The immobility time in FST and TST models were noted and compared with the standard imipramine. C. latifolium extract showed dose-dependent decrease in immobility time. Even though the mode of action of this extract is obscure, it is believed to be due to inhibition of the norepinephrine transporter as well as the serotonin transporter, enhancing their accessibility in the synaptic gap. It can be concluded that C.latifolium shows optimum antidepressant activity at a dose of 400mg/kg body weight.

Keywords: Depression, Crinum latifolium, Forced swim test, Tail suspension test, antidepressant activity.