Abstract

MYOSTIMULANT AND HYPOTENSIVE EFFECTS OF AN AQUEOUS EXTRACT OF SABA SENEGALENSIS (APOCYNACEA) LEAVES IN RABBITS

Dosso Mamadou*, Soro T. Yaya, Kacou N’ Guessan L. Francis and Traoré Flavien

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Abstract

Saba senegalensis, is a plant used for its multiple therapeutic virtues, in traditional medicine. It could be used in the treatment of constipation and hypertension, which is constantly gaining ground. Therefore, this study aimed to evaluate the myostimulant and hypotensive effects of an aqueous extract of the leaves of this plant, in rabbits. The myostimulant effect of the aqueous extract of the leaves of Saba senegalensis was evaluated using a fragment of rabbit intestine, 3 cm long, suspended between a hook and a writing pen, then kept alive in an organ tank containing glucosed and oxygenated Mac Ewen. A LUDWIG mercury manometer was used to evaluate the effect of this extract on blood pressure in an anesthetized rabbit whose carotid artery was exposed and intubated. The results of this work indicate that the aqueous extract of the leaves of Saba senegalensis for concentrations ranging from 2.10-1 mg/ml to 8.10-1 mg/ml increases the amplitude of rhythmic contractions of the rabbit intestine by 130 ± 3.7% to 244.29 ± 5.29% (P

Keywords: Saba senegalensis, myostimulant, hypotension, rabbit, cholinomimetic.