Abstract

THE EXPRESSION OF INTERFERON- ALPHA IN THYROID TUMORS CORRELATED TO HUMAN PARVOVIRUS B19 EXISTENCE

*Samar Abdul Raheem Al-Gharrawi, Ali Hussein Al-Khafaji,
Majid MohmmedMohmood Al-Jewari

Abstract

The present study was carried out to detect the expression of INF-α by immunohistochemical technique in Iraqi patients of malignant and benign thyroid tumors under the effect of parvovirus B19. A total number of (94) formalin-fixed paraffine-embeded thyroid tumors tissue collected from archivesdepartmentof histopathology laboratories during the period from July 2013 till November 2013. Tissue blocks were divided into three groups. First one included (53) tissue blocks of malignancy thyroid whereas the second group included (41) tissue blocks of benign thyroid tumors and the third group included (21) tissue blocks were selected from the same benign cases which have normal tissue. By using immunohistochemistry, B19 virus was detected in 66% of malignant and in 48.8%of benign tumors. INF-α expressed positively in 83% of malignant tumors compared to 63% of benign tumors, while it was detected only in 54 % of normal tissue.There was a significant correlation between human parvovirus B19 score category and INF-α score (r=0.296, p=0.031).It can be concluded that the expression of INF-α in thyroid tumors is significantly affected by the existence of human parvovirus B19.

Keywords: thyroid tumors, human parvovirus B19, Interferone –alpha.