Abstract

POTENTIAL BIOLOGICAL EVALUATION OF HYPOGLYCEMIC ACTIVITY OF LEAVES OF AGANOSMA DICHOTOMA

Md. Zahirul Islam Khan, Md. Reyad-ul-Ferdous*, Md. Iftekhar Hussain, Md. Atiqul Islam, Jakia Sultana, Md. Naimul Islam, Subash Pandaya, Manson Pandey

Abstract

The hypoglycemic effects of methanolic extract of Aganosmadichotoma were prepared from its leaves which were examined inSwiss-albino mice for conducting the experimental study. In doses of200 and 400 mg/kg body weight of Aganosma dichotoma were used tocompare with its standard Glibenclamide dose of 10 mg/kg bodyweight. Both doses of 200 and 400 mg/kg lowered the plasma glucosestatistically significant level in 3 hours administration with its standarddrug Glibenclamide. From this study it has been concluded that themethanolic extract of leaf of Aganosma dichotoma having goodhypoglycemic effect and increase in plasma insulin concentration.

Keywords: Aganosma dichotoma; Glibenclamide, Leaf extracts, Hypoglycemic activity.