Abstract

A REVIEW ON BIOLOGICAL ACTIVITY AND SYNTHETIC METHODS OF ISOINDOLE NUCLEUS

Dr. Sanjay Singh*, Gaurav Kumar, Manisha Negi and Babita Mehra

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Abstract

Isoindole is one of the most important heterocyclic compound, strong base than pyrrole, having varied biological activities and still of great scientific interest at this time. They are extensively found in bioorganic and medicinal chemistry with application in drug discovery. Isoindole is a benzo-fused pyrrole. The compound is an isomer of indole. Nitrogen atom constitutes the core structure of pyrrole and many pharmacologically and biologically active compounds. Isoindole is among the usually occurring heterocyclic nuclei in many natural plant products. Isoindole is known to exhibit a wide range of biological properties including, anticancer, antimicrobial, antimalarial, antiinflammatory, antibacterial, antifungal, antitubercular activities.

Keywords: Isoindole, pharmacological activities, antimicrobial activity, anti malarial activity, anti bacterial, antifungal activity.