Abstract

BI-LAYER TABLET TECHNOLOGY-OPENING NEW WAYS IN DRUG DELIVERY SYSTEM: AN OVERVIEW

Manisha D. Bhadange*, A. B. Darekar, R B. Saudagar

Abstract

Bi-layer tablet could be a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. Bi-layer tablets may be primary option to avoid chemical incompatibilities between APIs by physical separation and to enable the development of different drug release profiles. Therefore bilayer tablet is totally different facet for medicine, antiinflammatory, Anti hypertension, Anti diabetic, and analgesic. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. within the case of bilayered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper no adhesive layer its delivery occurs into the whole oral cavity.

Keywords: Bi-layer tablet, GMP needs, API, tablet press.