Abstract

NANOEMULSION: A BRIEF REVIEW ON DEVELOPMENT AND APPLICATION IN NOVEL DRUG DELIVERY SYSTEM (NDDS)

Omkar Atre*

.

Abstract

Nanoemulsions are colloidal dispersion systems that are thermodynamically, composed of two immiscible liquids mixed along with emulsifying agents (surfactants and co-surfactants) to form a single phase. Nanoemulsions are nanosized emulsion which are basically formed with the aim to improve the delivery of active pharmaceutical ingredient towards site of action. The drop size of nanoemulsion mainly falls in between the range of 20-200nm. Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as ultrafine dispersions whose differential drug loading; viscoelastic as well as visual properties can cater to a wide range of functionalities including drug delivery. This review aims to provide detailed information regarding various techniques of nanoemulsion preparation, formulation aspects of nanoemulsion and method of preparation, components of nanoemulsion, characterization of nanoemulsions and drug delivery applications of nanoemulsion.

Keywords: Nanoemulsions, amphiphilic surfactant, micro fluidization, entrapment efficiency.