Abstract

A REVIEW ON DISSOLUTION TEST APPARATUS WITH THEIR DIFFERENT MODEL

Mangesh Shinde*, Kedar Kunturwar, Sumit Wattamwar and Kapse Vidya N.

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Abstract

For orally administered non-solution dosage forms, in vitro performance test procedure such as dissolution test is performed for various purposes. It is widely used as the quality control tests for the oral solid dosage forms. The main uses of the dissolution testing include biopharmaceutical characterization of the drug product, as a tool to ensure consistent product quality and to predict in vivo drug bioavailability. Dissolution testing initially used for solid oral or orally non-solution dosage form, later on its use is widened to a variety of novel dosage forms. The research on dissolution from about 100 years ago as a field of physical chemistry. Apart from its importance in the field of pharmaceutical analysis it is also useful in pharmaceutical formulation technology and drug discovery. In this review paper we will focus on different mathematical aspects of dissolution process and different dissolution apparatuses are in use. The aim of review is detailed discussion on different types of dissolution apparatus.

Keywords: Dissolution, Apparatus, Dissolution testing, Dissolution Theories, Compartment model, pharmaceutical Application.