Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING TABLET OF LOSARTAN POTASSIUM

*Sonal B. Shinde and Deepali M. Pagire

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Abstract

The present study was to prepare a gastro retentive drug delivery system which offer the advantage in prolonging the gastric emptying time. Floating sustained release Losartan Potassium tablets were formulated by direct compression method. Losartan Potassium used in the treatment of Hypertension. The various type formulations were prepared by using hydrophilic polymers like HPMC K100M, ethyl cellulose, gas generating agents like Sodium bicarbonate and citric acid and active drug Losartan Potassium. The Floating tablets were evaluated for precompression and post compression parameters are solubility, uniformity of weight, hardness, friability, drug content, in vitro buoyancy studies, dissolution studies. The drug release profile and buoyancy properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the formulated batches showed better in-vitro buoyancy studies. It was observed that the tablet remained buoyant for 12-18 hours. The drug release mechanism from floating tablets was found to be Korsmeyer-Peppas equation. Thus the Floating system of HPMC K100M and Ethyl cellulose was found to be effective in regarding sustained release of Losartan Potassium Floating tablet. From the present study it is summarized that the developed formulation has good appearance with good handling condition, stable, therapeutically efficacious.

Keywords: Losartan Potassium, Floating, Gastro retentive drug delivery, Hypertension, Buoyancy.