Abstract

SPECTROPHOTOMETRIC DETERMINATION OF TERAZOSIN IN TABLET DOSAGE FORMS

K. Nagaraja Setty, G. V. Ranga Reddy. N. Rami Reddy*

Abstract

Two simple, accurate, rapid and precise spectrophotometric method has been developed for determination of terazosin in tablet dosage forms. The method A was based on the formation of chloroform extractable complex of Terazosin with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 585 nm against the reagent blank. Method B was based on the the charge transfer reactions of Terazosin as nelectron donor with acceptor, 2,5-dichloro-3,6-dihydroxy-1,4- benzoquinone. The absorbance of the highly intensive coloured solution was measured at 455 nm against reagent blank treated similarly.

Keywords: Terazosin, Spectrophotometry, Wool Fast Blue(WFB), 2,5-dichloro-3,6- dihydroxy-1,4-benzoquinone(DDQ), Formulations.