Abstract

EVALUATION OF ENHANCEMENT OF SOLUBILITY OF ASPIRIN BY SOLID DISPERSION TECHNIQUES USING DIFFERENT POLYMERS CONCENTRATION

Rohan R. Shirsat* and Sheeja Koliyote

Abstract

In the present study, the aim was to study the effect of carrier PEG 1500 & PEG 6000 on solubility and dissolution rate of aspirin. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by solvent evaporation, kneading and fusion method. Aspirin was formulated as physical mixtures and solid dispersions using 1:1, 1:2, and 1:4 ratios of drug and carrier (PEG 1500, PEG 6000). Saturation solubility study for pure drug, physical mixtures and solid dispersions were carried out in pH 6.8 phosphate buffer solutions (PBS). The In vitro dissolution studies were carried in pH 6.8, higher in vitro dissolution of solid dispersions were recorded compared to their corresponding physical mixtures and the pure drug. The prepared solid dispersions were observed that increased in the saturation solubility and dissolution rate of aspirin than that of pure drug. PEG 6000 in 1:4 drug to carrier ratio by fusion method exhibited the fastest drug release as well as highest saturation solubility. The prepared solid dispersions were characterized by solubility test, FT-IR spectroscopy, DSC study. Solid dispersion prepared with PEG 6000 in 1:4 ratio by fusion method shows the presence of amorphous form confirmed by the characterization study. The study also shows that the dissolution rate of aspirin can be enhanced to considerable extent by solid dispersion technique.

Keywords: Aspirin, solid dispersion, solubility, Fusion method, PEG-6000, kneading method, PEG-1500.