Abstract

ANALGESIC AND ANTI-INFLAMMATORY EFFECT OF METHANOLIC EXTRACT OF PHYSALIS ANGULATA ROOTS IN RATS

*Jyothibasu Tammu, K.Venkata Ramana, Sreenu Thalla

Department of pharmacology, A.S.N Pharmacy College, Tenali, Guntur, Andhra Pradesh, India.

Abstract

Methanolic extract of Physalis angulata roots were evaluated for analgesic and anti-inflammatory effects on Wistar rat model. Analgesic and anti-inflammatory potential of Physalis angulata roots at doses of 100, 200 mg/kg was evaluated against the standard drug indomethacin at a dose of 20 mg/kg, p.o. Wistar rats of either sex of six numbers in each group was undertaken for study and evaluated by acetic acid-induced writhing, hot plate reaction time, carrageenan-induced hind paw edema and safety test on gastric mucosa method. Methanolic extract of Physalis angulata showed anti-nociceptive effect in acetic acid-induced writhing characterized by a significant decrease in the number of writhings in rats (p < 0.01). In hot plate test, Physalis angulata showed nociceptive reaction towards thermal stimuli in rats and a significant increase in the reaction time was observed (p < 0.01). The test drug significantly inhibited the carrageenan- induced hind paw edema in rats that is indicative of the anti-inflammatory effect of Physalis angulata (p < 0.01). However, no gastric lesions were observed in Physalis angulata treated rats indicating the safety of test drug. The methanolic extract of Physalis angulata showed significant analgesic and anti-inflammatory effects in different animal models.

Keywords: Physalis angulata, roots, indomethacin, carrageenan.