Abstract

CYTOTOXIC EFFECT ON HUMAN OSTEOSARCOMA CELL LINE MG-63 AND ANTIMICROBIAL ACTIVITY ON CLINICAL PATHOGENS BY PLANT MEDIATED SILVER NANOPARTICLES

Ritika Chauhan, Mohammed Ibrahim, Shankar Narayanan and Jayanthi Abraham*

Abstract

The present investigation reveals the green synthesis of silver nanoparticles using Solanum nigrum and Cardiospermum halicacabum. The silver nanoparticles were synthesized and characterized by UV-Vis spectrophotometer (UV-Vis), Fourier transfer infrared spectrophotometer (FT-IR), X-ray diffraction (XRD), atomic force mass spectroscopy (AFM) and particle shape of the synthesized nanoparticles were determined by scanning electron microscopy (SEM). Furthermore, synthesized nanoparticles were evaluated for antimicrobial effect against various pathogens and cytotoxic effect on human osteosarcoma (MG-63) cell line. The plant mediated silver nanoparticles exhibited good antimicrobial activity against clinical pathogens and cytotoxic effect against bone cancer cells. Plant mediated silver nanoparticles possess therapeutic properties which may be useful in pharmaceutical applications.

Keywords: Plant extracts; Cytotoxicity effect; Green synthesis.