Abstract

CONCOMITANT ADMINISTRATION OF GLIBENCLAMIDE AND METOPROLOL ATTENUATES DOXORUBICIN INDUCED CARDIAC INFARCTION/TOXICITY VIA ELECTROPHYSIOLOGICAL INHOMOGENEITY DURING MYOCARDIAL ISCHEMIA

Prashant Kumar* and Dr A.R. Kulkarni

Abstract

In the present study, attenuation effect of concomitant administration of glibenclamide and metoprolol on cardiomyopathy / cardiotoxicity induced by doxorubicin via electrophysiological inhomogeneity during myocardial ischemia in albino wistar rats. Various parameters such as measurement of body and organ weight measurement, estimation of serum biomarkers, estimation of oxidative stress and histopathology were studied in two different models i.e., preventive and curative model. In this study we used Doxorubicin 2.5mg/kg body weight i.p. in six equal injection is for two weeks for a total cumulative dose of 15mg/kg body weight for cardiotoxicity and treatment with combination of glibenclamide and metoprolol. This treatment served as preventive model and curative model.

Keywords: Concomitant, Glibenclamide, Metoprolol, Doxorubicin.