Abstract

REVIEW ON METHODS OF PHARMACEUTICAL DENDRIMERS

Swati S. Pardhi* and Unnati T. Rathod

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Abstract

Dendrimersare highly branched molecule having a well-defined size, shape, molecular weight and monodispersity as compared to linear polymer. Dendrimers have tree like shape of consist of central core, branches and terminal group. The bioactive agent and may either be encapsulated into the interior of the dendrimers or they may be chemically attached or physically adsorbed onto the dendrimer surface. Dendrimer have wide application in pharmaceutical field in gene transfection as a diagnostic agent as blood substituent, as solubility enhancer surface modified dendrimers themselves may act as nano drugs against tumours, bacteria and viruses. This review focus on structure, property, method of synthesis, various methods of characterisation, application of dendrimers, formulation of dendrimers. Thebioactive agent can be easily encapsulated into the interior of the dendrimers.

Keywords: Dendrimers, Convergent, Divergent.