Abstract

FORMULATION AND EVALUATION OF PIOGLITAZONE TABLETS USING MANGIFERA INDICA GUM

Shubham Mishra*, Singh Shekhar Gautam and Amit Kumar Mishra

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Abstract

Diabetes mellitus is a complex metabolic disease in which a person has hyperglycemia (high blood sugar), either condition in which pancreatic β–cells does not produce insulin or impaired release of insulin due to insufficient or defective insulin receptors, and it also developed if insulin is not utilized by the body cell. Diabetes mellitus is mainly classified into two type, insuline dependent diabetes mellitus (type-I) and non –insulin dependent diabetes mellitus (type-II). Type –I diabetes occurs due to the cellular mediated autoimmune destruction of the β- cells of the pancreas. Type –II occurs at past middle age and common disease, in this there is no perdition of β-cells. Type-II is 95% expansion and Type –I is 5% expansion among diabetes. Polyuria (frequent urination), polydipsia (increased thirst), polyphagia (icreased hunger), blurred vision, diabetic dermadromes (skin rashes) are the symptoms of the diabetes mellitus (Chandrasekharetal.2010).

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