Abstract

FORMULATION AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SELECTED HERBAL MEDICINE

Abdur Rab*, Archana Singh and Nitendra Sahu

Abstract

The major active constituents are present in ethanolic extract in Solanum xanthocarpum and methanolic extract in A. officinarum rhizome. The developed herbal gel was greenish in color, translucent in appearance and showed good homogeneity with absence of lumps. Formulation F6 had good values of spreadability, viscosity, pH, drug content and during the accelerated stability studies the appearance was clear and no significant variation in spreadability, pH and drug content was observed. Four different concentration of extract 1mg/ml, 2 mg/ml, 4 mg/ml and 6 mg/ml were used for each plant extract. Among which ethanolic extract of S. xanthocarpum at concentration 6 mg/ml showed 50.1% protection of HRBC in hypotonic solution and A. officinarum extract at concentration 6 mg/ml showed 56.89 while combination of extract (1:1 ratio) at concentration 6 mg/ml showed 67.89% protection of HRBC in hypotonic solution. Percentage inhibition of edema by hydroalcohalic gel FH containing S. xanthocarpum and A. officinarum extracts containing was observed to be- 23.19% (at 1 hr.) and 46.23% (at 4 hr.). All the results were compared with standard voveran gel. The result revealed that formulations formulation FH containing both plants extract has potent anti-inflammatory action % Inhibition (Mean + SEM). Hydroalcoholic Gel formulation containing both plant extract FH and marketed products did not cause any skin reaction. It can be assured that both plants extract and the excipients did not cause any skin irritation and can be used in the gel formulation.

Keywords: Solanum xanthocarpum, Alpenia officinarum, rhizome, hydroalcohalic gel.