Abstract

PRESCRIBING PATTERN OF DRUGS IN HEPATIC IMPAIRMENT PATIENTS WITH OR WITHOUT COMORBIDITIES IN A TERTIARY CARE TEACHING HOSPITAL, DAVANGERE

Reshma Roy*, Ranjini T. P.*, Rajasree Reghunath, Pooja S. Raj, Dr. Santhosh Uttangi and Prof. J. S. Venkatesh

Objective: The study aims to evaluate the prescribing pattern of drugs

in hepatic impairment patients with or without comorbidities in a

tertiary care teaching hospital. Methodology: A prospective

observational study was carried out for 6 months in the in-patient

medicine department of Chigateri District Hospital, Davanagere. A

total of 130 case records of patients with hepatic disease were

reviewed and details such as demographics, specified drugs prescribed,

and medication errors are recorded. The collected data were analyzed

in MS Excel and descriptive statistics were used for analyzing the

result of the study. Results: One hundred and thirty consecutive

patients who met the inclusion criteria were studied comprising 117 (90%) males and 13

(10%) females. The majority of the patients were in the age group of 41-50 years. Most of the

patients were seen in the child grade B [85(66%)] and 93(72%) patients with MDF score <32.

The most predominant hepatic disease was found to be CLD associated with portal

hypertension [10(7.69%)] as comorbidity. Out of 1143 drugs, highly prescribed

hepatospecific drugs were diuretics [151(23.77%)] and non-hepatospecific drugs were

antibiotics [134(26.37%)]. Conclusion: Chronic liver disease was found to be more prevalent

in our study. There is considerable scope for improving prescribing patterns in CLD by

minimizing the use of medicines, and reduction of doses of drugs to reduce the consequences

of hepatotoxicity. Before prescribing to the patients, evaluation of medication with the suitable criteria or rational use of the drug must be strictly followed.

Abstract

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Keywords: Portal Hypertension, Chronic liver disease, rational drug use, comorbidity.