Abstract

FORMULATION AND EVALUATION OF MICROEMULSION OF CLOTRIMAZOLE AND BETAMETHASONE FOR TOPICAL DRUG DELIVERY SYSTEM

Dhurvendra Pratap Singh*, Aditya Tiwari and Nitendra Sahu

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Abstract

Micromulsion of Betamethasone and Clotrimazole which has enhanced solubility release and bioavailability properties with less inter and intra - subject variability would be desirable. Thus, it was aimed to formulate and evaluate emulsion of Betamethasone and Clotrimazole, max were determined at 245nm and 264nm respectively. Five different type formulations (E-1 to E-5) formed. All formulations were clear, there was no phase separation and Stable during Thermo dynamic changes, heating cooling cycle and centrifugation stressed test. Characterization of all emulsion formulations were evaluated for Droplet size, Zeta potential and Poly Dispersity Index (PDI) and %drug content, all emulsion showed excellent results droplet size was found between 1.12 to1.97μm. In-vitro Drug Release of gels of emulsion formulations were studied and found EG-1 (51.71), EG-2 (61.24), EG-3 (57.27), EG-4 (90.32) and EG-5(89.19) for Betamethasone and EG-1 (64.75), EG-2 (68.37), EG-3 (51.32), EG-4 (94.89) and EG-5(88.32) for Clotrimazole. Formulations EG-4 was found excellent on the basis of cumulative % of drug release profile. Release data of selected formulation EG-4 was fitted into kinetic models. Drug release data were fitted into the zero order, first order, Higuchi and Peppas-Korsemeyer model of drug release kinetics. Formulation EG-4 was followed Zero Order Kinetics explained as continuous and steady release of both drugs from the formulation EG-4.

Keywords: Micromulsion, Betamethasone, Clotrimazole, bioavailability, gel.