Abstract

ANTIMICROBIAL ACTIVITY OF SOME NATURAL PRODUCT AGAINST INFECTED WOUND IN RAT MODEL WITH MDR

Asmaa Sayed, Fatma Mokhtar Fouda, Safaa Shawky Hassan and Marwa T. Hassen*

.

Abstract

Blood cultures used to detect microorganisms infecting blood. Bacteria may disseminate to blood stream leading to bacteremia which may developed to harmful consequences to body. 53 blood cultures were collected from pediatric cancer patients and investigated for their bacterial load. Most common bacterial isolates were E. coli, MRSA and klebsiella pneumonia. Pomegranate peel and miswak are natural products with various applications. Pomegranate peel and miswak extracts were tested against most common bacterial isolates and showing a very promising results. In vivo animal wound infection model were performed to compare effect of using traditional antibiotics alone or combined with pomegranate peel or miswak. Macroscopic examination of skin was done to various treatments. Histological and physiological investigations for various testing groups reflecting the synergistic effect of natural products with antibiotics to enhance healing process. The present results highlight the possibility to use certain natural products for some beneficial uses after more verifications of results.

Keywords: Bacteremia; Pomegranate peel; Miswak; Inflammatory markers; Oxidative stress.