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Abstract

PRE-CLINICAL TOXICITY STUDIES OF NEEM [AZADIRACHTA INDICA] IN MICE AND RATS

Dr. Rajendra Kumar Singh*

Abstract

The present study has been conducted to assess the Pre-Clinical safety and efficacy of Neem [Azadirachta indica] leaves in mice and rat model. Albino mice (Swiss) were used in graded doses of Azadirachta indica by oral routes. Acute toxicity of Azadirachta indica showed normal behaviour and no mortality up to the 14th day. Effect of Azadirachta indica on haematological, biochemical and histopathological parameters in sub –acute toxicity was carried out. Sub-acute toxicity of Azadirachta indica was found no significant changes in haematological, biochemical parameters and histopathological examinations.

Keywords: Azadirachta indica: Acute- toxicity: Sub- Acute- toxicity: Histopathology.


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