Abstract

DESIGN AND SYNTHESIS OF BENZYLIDENE THIAZOLIDINE-2, 4- DIONE DERIVATIVES WITH THEIR ANTICANCER AND ANTIDIABETIC BIOLOGIAL SCREENING

*Tahseen Akhtar, Bharti Saini, Abdul Rahman Khan and Atul Kumar

Abstract

The present work discloses the synthesis of six novel benzylidene thiazolidine-2, 4-dione derivatives synthesized using 5-(4- hydroxybenzylidene) thiazolidine-2, 4-dione and their biological evaluation as anticancer and antidiabetic agents . The synthesized compounds were screened for PTP-1B inhibitory activity as well as anticancer activity. In this study we have used cancer cell lines DLD-1 and SW620 (colon cancer cell lines) and MCF-7 MDAMB-231 lines (breast cancer cell lines). For antidiabetic activity PTP 1B inhibitory action was observed and MIC values are found in μM concentration. Out of the screened compounds 5-(4-(prop-2-ynyloxy) benzylidene)-3- (prop-2-ynyl) thiazolidine-2, 4-dione (compound 9) was found to be active against PTP-1B and 5-(4-(7-chloroquinolin-4yloxy)benzylidene)thiazolidine-2,4-dione (compound 5) has been found to show activity against MDAMB-231 cell line as anticancer agent.

Keywords: thiazolidine, anticancer, antidiabetic.