Abstract

EVALUATION OF ANTICONVULSIVE AND SEDATIVE EFFECT OF BRILLANTAISIA PATULA LEAVES T. ANDERSON IN MICE

Bassoueka D’Avila Judicaël*, Silaoh Maleka Emmanuellia Divine, Fourika Daisy Christie, Okassa Poma Chancelia Inès and Abena Ange Antoine

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Abstract

In Congo, Brilllantaisia patula, is a plant used in traditional medicine due to its many virtues including anticonvulsant and sedative effects. Therefore, this study aims to assess the anticonvulsant activity of the extracts of Brilllantaisia patula leaves in doses of 250 and 500 mg/Kg. The results obtained showed a significant effect of the aqueous extract of the B. patula leaves on the time of onset of convulsions. Concerning the sedative activity, the aqueous extract of the Brillantaisia patula leaves has a significant effect at dependent dose on the motricity of animals. On the other hand, the effect is not significant on the duration and the time to onset of the sleep.

Keywords: Brillantaisia patula, Anticonvulsant effect, Sedative effect, Therapy, Brazzaville.