Abstract

EFFECT OF COENZYME Q10 AND CARVEDILOL ON CYCLOSPORINE A INDUCED CARDIOTOXICITY IN RATS

Dr. Mostafa F. Mohamed*

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Abstract

Cyclosporine-A is most frequently used in transplant medicine. However, the major limiting factors in its use are nephrotoxicity, hepatotoxicity and cardiotoxicity. Aim: The aim of this work is to study the effect of each of coenzyme Q10 and carvedilol alone and in combination on cyclosporine-A induced cardiotoxicity in rats. Methods: This study was carried out on 50 male albino rats divided into 5 equal groups: Group 1 (Normal control), Group 2 (Received Cyclosporine-A), Group 3 (Received Cyclosporine-A + Carvedilol), Group 4 (Received Cyclosporine-A + CoQ10), Group 5 (Received Cyclosporine-A + CoQ10+ Carvedilol). Tissue SOD, CAT, GSH-Px activity, MDA, NO and serum CK-MB and AST were measured. Histopathological examination of the heart was performed. Results: Cyclosporine-A induced significant decrease in tissue SOD, CAT, GSH-Px activities and significant increase in tissue MDA, NO and serum CK-MB and AST compared to normal control group. Administration of either carvedilol or Q10 induced significant increase in tissue SOD, CAT, GSH-Px activities and significant decrease in tissue MDA, NO and serum CK-MB and AST compared to CsA group. Concomitant administration of carvedilol and Q10 induced significant increase in tissue SOD, CAT, GSH-Px activities and significant decrease in tissue MDA and NO and serum CK-MB and AST compared to CsA group which was more marked than each of coenzyme Q10 and carvedilol alone. Conclusion: This demonstrates the cardioprotective effect of coenzyme Q10 and carvedilol alone and in combination against cyclosporine A induced cardiotoxicity.

Keywords: Coenzyme Q10, Carvedilol, Cyclosporine A, cardiotoxicity, rats.