Abstract

SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

M. Mohan Varma, K. T. Sunil Kumar, K. R. N. Mounika Devi, J. Erusha, K. Viswaja*, M. V. Sowmya

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Abstract

Self nanoemulsifying drug delivery systems enhance the solubility of poorly water soluble drugs. It is an isotropic mixture of oil, surfactant, co-surfactant molecules, which spontaneously form o/w nanoemulsion upon dilution with water under gentle stirring. They are highly in quest due to their innumerable benefits like better portability, improved stability and bioavailability, they are having a size of globules less than 100 nm. The SNEDDS is an important application of BCS class II and class IV drugs for improving solubility of poorly water soluble drugs. It is important to prevent the interfacial tension and improve the dissolution as well as absorption rate of drug molecules. This review mainly focuses on the components, mechanism of self emulsification, preparation, characterization, and applications and future perspectives of SNEDDS.

Keywords: Self-emulsifying system, Triglycerides, Surfactant, Pseudoternary phase, Droplet size.