Abstract

POTENTIAL OF BENZIMIDAZOLE AS ANTI-DIABETIC AGENT: REVIEW

S. S. Nikam*, A. S. Kulkarni, R. D. Chakole and M. S. Charde

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Abstract

Benzimidazole is aromatic, nitrogen containing compound and privileged scaffold with active pharmacophore in medicinal chemistry. They exhibit immense pharmacological and biological activities which resulted in development of several classes of drugs. The review confers about the synthesis of benzimidazole derivatives as target agents for anti-diabetic activity by inhibiting enzyme α-amylase and α- glycosidase. Diabetes mellitus is chronic metabolic disease, mainly hyperglycemia results in deficiencies like insulin secretion or insulin action or both. Research describes that α- Glycosidase inhibitors (AGI’s) and α-amylase inhibitors (AAI’s) are unique class of drugs that are capable to reduce type II diabetes.

Keywords: Benzimidazole, Anti-diabetic, ?-amylase inhibition, ?-glycosidase inhibition.