Abstract

A REVIEW ON HYDROTROPY: THE APPROACH TOWARDS GREEN CHEMISTRY

Saundarya S. Patil* and Akanksha S. More

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Abstract

The discovery and development of new drugs benefit human beings and play a significant role in the world. The solubility of drugs is one of the primary factors to be taken into account and given attention in the development of drugs in the pharmaceutical industry. Among the newly discovered drugs, for both lipophilicity and solubility, drugs with low water dispersibility are responsible for around 40% of market failures. Initially, there was a barrier to both development and clinical testing, while now, examine the pharmacological effects of new drugs. These days, the oral route is accommodated route for drug delivery as compared to other methods because of its administrative simplicity and cost-effectiveness. Hydrotropic solubilization technique is one of the methods that has been used to improve the solubility of poorly soluble drugs to prevent these problems. Also, the benefit of specific qualities, such as excellent selectivity, non-flammability, environmentally friendly, ease of availability, and cost affordability make this method beneficial and also preferable to other methods of solubilization. These days, hydrotropic agents are useful to produce various dosage forms, including injections, orally disintegrating tablets, and solid dispersions. In this review, an effort has been made to display the hydrotropic solubilization method is the approach to green chemistry.

Keywords: Solubility, Hydrotropy, Hydrotropic agent, Poor water soluble drugs, Mixed hydrotropy, Green chemistry.