Abstract

FORMULATION AND EVALUATION OF ASCORBIC ACID EFFERVESCENT GRANULES

Pratiksha S. Londhe*, Poonam D. Khalate, Bharatee P. Chaudhari, Vivekkumar K. Redasani

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Abstract

Effervescent granules have occupied a unique place in the field of pharmaceutics. Widely use in clinical diagnosis of heart burn, urinary tract infection, acidity. The aim of these study to design and optimize effervescent granules of ascorbic acid. Eight different formulation of ascorbic acid effervescent granules was prepared and formulations are made up of chemical ingredients such as citric acid, tartaric acid, sodium bicarbonate and calcium carbonate. Effervescent granules were prepared by heat or fusion method. The study also focused on the water of crystallization concept which is related to the reaction between citric acid, tartaric acid and sodium bicarbonate. Evaluation test were performed such as disintegration test, amount of carbon dioxide, pH of formulation. There were eight different formulation prepared and denoted as F1, F2, F3, F4, F5, F6, F7 and F8. Fifth formulation that is F5 gives precise result. They give significantly low disintegration time, pH within range and also amount of carbon dioxide in accepted range. F5 give significant result as compared to other formulations.

Keywords: Effervescent granules, Disintegration time, Damped mass, Heat method, Water of crystallization, Ascorbic acid.