Abstract

DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF NATURAL GUM BASED MATRIX TABLET OF INDOMETHACIN

Abhijeet Anand*, Vivek Kumar Patel, Anupam Singh Bhadouriya and Pramod Kumar Biswal

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Abstract

The main objective was to develop matrix tablets (Sustained release) of IM (indomethacin by the help direct compression method. IM (Indomethacin is a NSAID’S (non-steroidal Anti-inflammatory drug’s). Indomethacin (IM) is a COX (cyclooxygenase) inhibitor. IM (sustained) release matrix of IM (Indomethacin) was formulated by the help of relatively less used matrix forming material Gum copal and gum damar. IM (Indomethacin) solid dispersion was prepared by the of PEG4000 and PVPK30. The dissolution (rate) of IM (Indomethacin) is first enhanced by the help of dispersion the drug in hydrophilic polymer (PEG) 4000 and the dispersion is the enclosed in the matrix of gum copal and gum damar. Indomethacin separate ration of Indomethacin (IM) and gum copal were engaged and the dispersion (solid) were prepared by melting and solvent method. IR (Infrared spectroscopy) studies display that there are no any interaction among IM (Indomethacin) and PEG4000. The granules appears good flow characteristics and test carry out within the standards.

Keywords: Indomethacin, Gum damar, Gum copal, Peg-4000, Matrix tablet, Sustained Release, PVPK30.