Abstract

FORMULATION AND OPTIMIZATION OF ANTI-EPILEPTIC DRUG DELIVERY SYSTEM FOR FAST DISSOLVING INTRAORAL DRUG DELIVERY

Abhishek Mishra*, Prashant Kumar Upadhyay and Abadhesh Kumar Niranjan

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Abstract

Repeated seizures are a symptom of the neurological illness known as epilepsy, which affects people of all ages. The drugs used to treat epileptic seizures are known as antiepileptic drugs because they are known to lessen the frequency or severity of seizures. Intra dental medication shipping and delivery has multiple benefits such as for instance quick dissolution, fast absorption through dental mucosa as well as making it possible for total disintegration just before swallowing for brief healing activity. Fast dissolving capsules of clobazam had been ready utilizing thirty-two complete factorial design layouts by immediate compression method. The in vitro disintegration period was discovered to have the assortment of 28.3-193sec. The tablet formula DtF17 that contains 6% of superdisintegrant (crospovidone) as well as thirty % of diluent (MCC) was found to have least disintegration time against any other preparations.

Keywords: Intra-oral drug delivery, Fast dissolving system, superdisintegrant, antiepileptic drug, crospovidone.