Abstract

PREPARATION AND CHARACTERIZATION OF SURFACTANT FREE GLIBENCLAMIDE NANOPARTICLES

Dr. Nagaveni Pommala*, Sai Sowmya Dandu, Dr. AppaRao Chippada

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Abstract

The aim of the present study involved is the Preparation and characterization of surfactant- Free Glibenclamide Nanoparticles. Wherein the polymer used for the Preparation of Glibenclamide Nanoparticles were Eudragit RLPO and PEG with Various molecular weight. Glibenclamide nanoparticles were obtained by nanoprecipitation and evaluated in terms of drug content, encapsulation efficiency, apparent saturation solubility, drug release profile, solid state and storage stability. The particle size, size distribution and zeta potential of the nanoparticles was investigated by using the stirring speed. Results Revealed that by increasing the molecular weight of PEG decreases the drug encapsulation and dissolution rate of the drug increased. Stability studies confirmed that glibenclamide Nanoparticles were stable even after 150 days. The prepared surfactant- free glibenclamide nanoparticles represent a promising alternative to enhance the treatment of non-insulin dependent diabetes.

Keywords: Glibenclamide, Nanoprecepitation, Bottom up Approach, Surfactant Free, Eudragit.