Abstract

COMPARISON OF DISINTEGRATION TIME OF FORMULATED LOSARTAN POTASSIUM FDTS BY USING NATURAL AND SYNTHETIC SUPER DISINTEGRANTS

Dr. Nagaveni Pommala*, Satheesh Kumar Nimma, Derangula Ruthu Kumari and Dr. Appa Rao Chippada

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Abstract

Losartan potassium is used as an anti-hypertensive drug but it undergoes first-pass metabolism due to its low bioavailability. Fast onset of action is very important in the management of hypertension. Therefore, the aim of the study is to formulate the FDTs of Losartan Potassium to improve its bioavailability, rapid onset of action, and increase patient compliance. In the present study, we have to formulate the Losartan Potassium FDTs by using natural [Banana starch]and synthetic [sodium starch glycolate] super disintegrants, FDTs which are formulated by using Banana starch have the enhanced dissolution rate, drug release, and decreases the disintegration time and Rapid on set action when compared with FDTs formulated by using synthetic super disintegrant [sodium starch glycolate].

Keywords: Super disintegrants, Banana starch, Sodium starch glycolate, Disintegrating efficiency, Bioavailability, Dissolution rate.