Abstract

FORMULATION AND EVALUATION OF METFORMIN HCL EFFERVESCENT FLOATING TABLETS

Umadevi Uppara*, Dr. K. Muniraja Lakshmi, Dr. AppaRao Chippada

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Abstract

The aim of the present study involved the formulation and evaluation of metformin hydrochloride effervescent floating tablets. Two hydrophilic polymers are used at various concentrations (10, 12.5, 15 and 17.5%), xanthum gum and hydroxypropylmethylcellulose (HPMC) at three viscosity grades (K4M, K15M and K100M). The results have shown the effect of nature of hydrophilic polymer on the biopharmaceutical behavior of metformin HCl floating tablets. The prepared tablets were evaluated for number of parameters like Thickness, Hardness, Weight variation, Friability, Drug content uniformity, Floating lag time, Floating time and in vitro release studies. The drug release kinetic was found to be dependent on HPMC viscosity, particularly at the concentration 17.5%. The floating tablets F8 (HPMC K15M) and F12 (HPMC K100M) have exhibited extended release kinetics (>8 hours) with release rates of 92.18+1.09 and 80±1.14% respectively.

Keywords: Metformin HCL, HPMC, Xanthum Gum, Granulation.