Abstract

CURCUMIN POTENTIATES THERAPEUTIC EFFICACY OF VOGLIBOSE

Diksha B. Khandale*, Vitthal J. Chaware, Vivekkumar K. Redasani and Ashish T. Thorat

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Abstract

Introduction: Herbal antidiabetic preparations are often used as an add-on therapy in diabetes and such herbal preparations often contain curcumin. Hence, in the present investigation the combine effects of curcumin and voglibose in normal as well as diabetic rats was studied. Methods: Streptozotocin (60 mg/kg i.p.) diabetic rats was treated for 14 days with curcumin (30 mg/kg p.o) and voglibose (0.06 mg/kg p.o). After treatments, the blood glucose level was assessed. Data was analyzed using one-way analysis of variance (ANOVA) followed by post hoc Scheffe's test. Results: Treatment of diabetic rats with curcumin or voglibose alone decreased the blood glucose level. The combination of voglibose with curcumin further decreased blood glucose levels in diabetic rats, indicating synergestic effect. Conclusion: The results highlights that curcumin and voglibose given alone showed effect against STZ induced Hyperglycemia but the combination of curcumin with voglibose showed better and synergistic effect. Therefore, it might be a promising strategy for combating diabetic complications.

Keywords: Hyperglycemia; Curcumin; Voglibose; Streptozotocin; Antidiabetic activity.