Abstract

FORMULATION AND EVALUATION OF NANOGEL FOR TOPICAL ACTION IN RHEUMATOID ARTHRITIS

*Nidhi Raturi, Popin Kumar, Praveen Kumar Ashok

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Abstract

Ointments are made from animal, minerals & plant extracts that were widely utilized in Egyptian & Babylonian healthcare in 3000BC. Nanogels (nanosized hydrogels) are small, swelling particles formed of adaptable hydrophilic or amphiphilic polymer networks that have been mechanically or chemically cross-linked. This research focuses on formulation and characterization of etodolac nanogel for potent antirheumatoid arthritis potential by using standard parameters. Etodolac's nanogel was created using a modified emulsification-diffusion technique. Preformulation study was performed in terms of solubility, drug-excipient compatibility. Standard calibration curve was plotted of Etodolac. After that formulation was estimated in terms of pH, Spreadability, In-vitro drug release, particle size & PDI, % drug content, RF etc. To confirm the anti-arthritic activity, rats were divided in 3 groups; Group 1: animals are applied only nanogel base once a day, up to 15 days; Group 2: animals are injected 0.1ml complete fruend's adjuvant once a day, up to 15 days. Group 3: animals are injected 0.1ml complete fruend's adjuvant + nanogel (NG0-NG6) orally. In all the parameters, NG showed an excellent formulation property when observed. Physical appearances were optimistic in terms of better clarity and transparency of the emulsions. After 30 days, when stability parameters performed in terms of pH, % drug content and in-vitro drug release, they all were almost similar to previous evaluations. Nanogel treated rats showed a marked decrease in RF when estimated that suggests for its anti-rheumatoid arthritis potential. While maximum action was seen in NG1 treated rats.

Keywords: Nanogel, etodolac, topical, anti-arthritic activity, analgesic.