Abstract

PREPARATION AND CHARACTERIZATION OF GRISEOFULVIN NANOPARTICLES BY IONOTROPIC GELATION METHOD

Vothani Sarath Babu*, Karra Naga Venkata Sai Raju, Prudhvi Guru Yachendhra, Chippada Appa Rao

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Abstract

The main objective of this work was to prepare and characterize chitosan loaded Griseofulvin nanoparticles. The FTIR and DSC studies were carried out for pure drug, polymer and drug with polymer in different ratio which shows there was no chemical interaction between the drug and polymer. The F4 formulation shows more entrapment efficacy compared to other formulations nearly 92.87% and the drug content was found to be 96.7%. The particle size and the surface morphology results revealed that griseofulvin nanoparticles (GNPs) were smoothed spheroidal with a size ranging from260 nm-632 nm. The invitro dissolution studies were carried out for all the Formulation. Formulation F4 shows 97.67% of drug release at the end of 24 hr. The results suggest that chitosan polymer based nanoparticulate formulations are potential means to achieve release of Griseofulvin for the prolonged period of time for effective therapy. The results showed that this method is reproducible easily.

Keywords: Griseofulvin, Nanoparticles, Chitosan, Inotropic gelation method.