Abstract

EFFECTS OF VERAPAMIL AND FERULIC ACID AGAINST CHEMICALS INDUCED CONVULSIONS IN ALBINO MICE

Prajakta S. More*, Vitthal J. Chawre and Vivekkumar K. Redasani

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Abstract

Background: The currently available antiseizure drugs have a low therapeutic index and provided emerge satisfactory seizure control in only 60-70% of patients. Calcium channel blocker have shown potentials of a useful add-on drug for the available antiepileptic drugs. Role of oxidative stress in epileptogenic process has been supported in various studies. Objectives: To study Potentiation effect of verapamil and Ferulic acid against pentylenetetrazole and picrotoxin induced convulsions in mice. Methods: For this study, swiss albino mice were used. Effects of verapamil and ferulic acid alone and in combination with diazepam (4mg/kg) were studied. Onset of convulsions and duration of convulsions, percentage protection was considered as the index for antiepileptic activity. Result: Verapamil (20mg/kg) produced non significant antiseizure effect and ferulic acid at dose (75mg/kg) reduced the convulsions and myoclonic jerk but verapamil and ferulic acid in combination with diazepam potentiate the antiepileptic effect. Conclusion: Verapamil and ferulic acid potentiated the antiepileptic effect of diazepam. Dose of diazepam can be reduced in epileptic patient receiving verapamil and ferulic acid.

Keywords: Verapamil, Diazepam, Ferulic acid, Picrotoxin induced seizures, Pentylenetetrazole induced seizures.