Abstract

DEVELOPMENT OF MUCOADHESIVE GEL FOR NASAL DELIVERY OF NOISOME LOADED WITH NIMODIPINE

Parthiban S. and Saritha A. N.*

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Abstract

The aim of the present investigation was to formulate and evaluate a niosomal mucoadhesive gel containing Nimodipine. Niosomess were prepared by the thin film hydration method by using methanol as a solvent. Niosome containing Nimodipine formulations were prepared by different concentration of span 60 and cholesterol by thin film hydration technique. These formulations were evaluated for entrapment efficiency, particle size, zeta potential and in vitro drug release. Particle size and zeta potential of the F4 formulation was found to be 1256 nm, -48.1 mV respectively. The highest entrapment efficiency and drug content is observed in F4 niosomal formulation with 96.96% and 95.54% respectively. Since the formulation F4 showed maximum amount of %drug content, %drug entrapment efficiency, and drug will release in controlled manner for prolonged time. and hence F4 niosomal formulation were selected as optimized and further used for nasal niosomal mucoadhesive gel by using the Carbopol 934 at 3% w/v as a polymer (gelling agent). Further the prepared gel (GF4) was evaluated for Ex-vivo permeation study for 12 hours and it shows maximum amount of drug release in a controlled manner, further mucoadhesive nasal gel was evaluated for the mucoadhesive strength (13.22±1.05) and viscosity (9450 cps). Hencethe results clearly showed that the gels have ability to retain the drug for prolonged periods. The % CDR of mucoadhesive niosomal gel formulation GF4 was found to be 96.16% and which follows zero order. The ‘n’ values for all the formulation were found to be more than 0.5. this indicates that the release approximates non-fickian diffusion mechanism.

Keywords: Niosome, Mucoadhesive gel, Nimodipine, Carbopol 934, nasal drug delivery span 60.