Abstract

FORMULATION AND EVALUATION OF ETHENZAMIDE EMULGEL

*B. Swathi, Fareeha Tasneem, Mahveen Fatima, Azmat Unnisa Begum, Mariam Bint, Mohammed Bin, Bader Bin and Habsa Al Jabri

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Abstract

Emulgel is one of the recent technologies in the Novel drug delivery system used for dual control release of emulsion and gel for topical use. The method used for the preparation of microemulsion w/o was the water titration method with Liquid paraffin and propylene glycol as oil phase, Tween 80 and Span 80 are used as surfactants and its concentration were fixed based on pseudo ternary phase diagrams. The optimized emulsion formulation was incorporated into the gel matrix that is Carbopol-934, HPMC-5, and HPMC-15 + Carbopol-934 by using various concentrations. The prepared Emulgel was characterized for drug content, physical appearance, pH, viscosity, spreadability, extrudability, and in vitro drug release studies. The optimized formulations showed F9 with 1:3 HPMC-15 + Carbopol-934 formulations showed in vitro drug release of 97.82% at the end of 5 hours. The optimized formulation showed good drug release within the specified limits. Ethenzamide was proven to be a suitable candidate for formulating Emulgel for topical delivery to achieve better patient compliance.

Keywords: Ethenzamide, Emulgel, Topical application, Carbopol-934, HPMC-5, HPMC-15 + Carbopol-934, Liquid paraffin, Tween 80, Span 80, and Propylene glycol.