Abstract

A REVIEW OF LIPOSOMES AS A GOOD CARRIER FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Bharati R. Gondane*, Dr. Dinesh M. Biyani and Dr. Milind J. Umekar

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Abstract

Liposomes are explored in this review paper. A liposome is a microparticulate colloidal vesicle with one or more concentric layers of phospholipids surrounded by aqueous medium. Liposomes have the advantages of reduced toxicity and enhanced stability. The leaking and fusion characteristics of liposomes are drawbacks. Phospholipids, sterol, Sphinogolipids, and other substances are the four primary structural components of liposomes. Liposomes are prepared using a variety of methods, including solvent dispersion, Sonication, ethanol injection, and ether injection. To better understand the transdermal medication delivery mechanism of liposomes. It also interacts to the keratin in the horny layer of the skin, allowing it to penetrate deeper into the skin and provide improved absorption. Amphotericin-B, marketed under the brand name Abelcet, is a liposome formulation used to treat invasive severe fungal infections.

Keywords: Liposomes, Phospholipids, Sterol, liposomes transport drugs transdermally, Keratin.