Abstract

SOLUBILITY ENHANCEMENT OF DICYCLOMINE USING SOLID DISPERSION TECHNIQUES

*Shaundarya Kumar¹, Usha Rai² ,Rakesh singh², Vaibhav Prakash Srivastava²

¹Kamala Nehru Institute of Technology & Management, Faridipur, Sultanpur UP, India

Abstract

The aim of the present study is to formulate and study of Solubility Enhancement of Dicyclomine Using Solid Dispersion Technique containing Dicyclomine in different drug to polymer ratio by Kneading Method. The cyclodextrin complexes formulated by employing 1:1 (drug: complexing agent) with kneading technique showed higher drug release. β - CD was mixed in glass mortar along with water to obtain a homogeneous paste. The drug was then slowly added to the paste and the mixture was triturated for 1 hr. during the process the water content was empirically adjusted to maintain the consistency of the paste. The paste formed was dried under vacuum for 24 hours. Dried powder was passed through specific sieve no. and stored in a dessicator until further evaluation. A high surface area is formed which results an increased dissolution rate and further improved the bioavailability of the poorly water soluble drug. Particles with improved wettability: The solubility enhancement of the drug is related to the drug wettability improvement verified in solid dispersion . Particles with higher porosity : Particles in solid dispersions have been found to have a higher degree of porosity and the increase in porosity also depends on the properties of the carrier. In order to enhance in vitro dissolution and content uniformity of poorly soluble drug dicyclomine by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using PEG 6000 and β – cyclodextrin (as carrier).

Keywords: Kneading Method; solid dispersion; Dicyclomine; inclusion complex, β – cyclodextrin, PEG 6000 physical, kneading, solvent evaporation & fusion method.