Abstract

NEW INSIGHTS INTO ANTI-TUBERCULAR POTENTIAL OF TRIAZOLE SCAFFOLD

*Rina Das and Dinesh Mehta

Abstract

TB is a worldwide problem and it is a global health emergency. The current problem of tuberculosis therapy is caused by the improper use of antibiotics in chemotherapy of TB patients which gives rise to multi-drug resistant (MDR) strains. Triazoles are heterocyclic compounds featuring five member ring of two carbon atoms and three nitrogen atoms as part of the aromatic five-member ring and possess almost all types of biological activities. This diversity in the therapeutical response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Present article is sincere attempt to review chemistry, synthesis, spectral studies of triazoles and to study triazoles synthesized in last few years which have shown potent antitubercular activity.

Keywords: Antitubercular activity, Antitubercular drugs, Triazoles, Tuberculosis (TB).