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Abstract

FIXED DOSE COMBINATION-RATIONALE, USES, ADVANTAGES, AND DISADVANTAGES-A BRIEF REVIEW

Dr. Virendra Kushwaha, Dr. Pooja Agrawal*, Dr. Tanvi Azmi, Dr. Vipul Shukla, Dr. Arka Das

Abstract

More than one drug is frequently used for the treatment of either a single ailment or multiple comorbid conditions. Sometimes, two or more drugs are combined in a fixed ratio. Fixed dose drug combinations (FDCs), are combinations of two or more active drugs in a single dosage form. Fixed ratio combination products are acceptable only when the dosage of each ingredient meets the requirement of a defined population group and when the combination has a proven advantage over single compounds administered separately for a therapeutic effect, safety, or compliance. The rationality of FDCs should be based on certain aspects such as the drugs in the combination should act by different mechanisms, The pharmacokinetics must not be widely different, and the combination should not have supra-additive toxicity of the ingredients. FDCs are classified into 4 categories. There are several concerns with FDCs clinical, economical and general. For FDCs to work appropriately and resolve concerns, pharmacovigilance of FDCs is required.

Keywords: Fixed Dose Combination, Rationale, Dose, Effects, Patient.


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