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Abstract

ACUTE ORAL TOXICITY STUDY OF NANO VIJAYSAR(PTEROCARPUS MARSUPIUM ROXB) HYDRO ALCOHOLIC EXTRACT IN SPRAGUE DAWLEY RATS

Dr. Kruti Tandel*, Dr. Shailesh V. Deshpande, Dr. Arun K. Soni and Dr. Yakshi Choudhary

Abstract

Herbal medicines are considered to offer gentle means of managing chronic diseases from the decades. Vijaysar (Pterocarpus marsupium Roxb) is widely use in Ayurveda for the management of various metabolic disorder including hyperglycemia. The wood and bark of Vijaysar (Pterocarpus marsupium Roxb) is exhibits significant antidiabetic, hepatoprotective, anti-oxidant and cardio-tonic activities. Aim of study: The present study was carried out to evaluate the safety of nano Vijaysar (Pterocarpus marsupium Roxb) hydro alcoholic extract (NVE) by determining toxicity after acute oral administration in Sprague dawley rats. Materials and methods: The acute toxicity test was conducted in Sprague Dawley rats by administrating single oral dose 2000mg/kg of NVE within the observation period of 14 days for mortality and clinical symptoms. Result: Oral administration 2000mg/kg of NVE resulted in zero mortality with no evidence of adverse effects, implying that NVE is nontoxic and LD50 is more than 2000mg/kg. Throughout 14 days of the treatment, there were no changes in behavioral pattern, clinical sign and body weight of rats in both control and treatment groups. Also, there were no significant elevations observed in the biochemical analysis of the blood serum. Further, histopathological examination revealed normal architecture and no significant adverse effects observed on the kidney, heart, liver, lung and spleen. Conclusion: The result showed that LD50 of NEV is more than 2000mg/kg. Thereby, in the absence of toxicity in oral high dose administration indicates that the formulation could be considered safe for medication in humans.

Keywords: Ayurvedic medicine, Anti-diabetic drug, Nano particles.


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