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Abstract

EVALUATION OF ANTICATALEPTIC ACTIVITY OF BACLOFEN ON HALOPERIDOL & PILOCARPINE INDUCED CATALEPSY

Shriram D. Virkar*, Atish B. Velhal, Vitthal J. Chaware and Vivekumar K. Redasani

Abstract

Aim: Evaluation of Anticataleptic activity of baclofen on Haloperidol & Pilocarpine induced catalepsy. Materials and methods: A cataleptic behaviour was measured with a high bar test method. Catalepsy score was measured each hour for 4 h after haloperidol and pilocarpine administration, by gently placing both the forepaws of the rat over a metal bar (diameter 2–5 mm) situated 6 cm above the tabletop. The intensity of catalepsy was assessed by counting the time in seconds until the rat brought both forepaws down to the tabletop, with a maximum cut-off time of 180s. Result: Haloperidol 1mg/kg p.o and Pilocarpine 100mg/kg p.o caused a time dependent increase in catalepsy, with maximum score occurring at 4 hours after administration. Animal treated by Baclofen (10mg/kg) p.o could significantly reduce catalepctic score as compared to toxicant control animals. Conclusion: It is concluded that Baclofen at the dose of 10mg/kg p.o can possess anticatalepctic effect.

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