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Abstract

SAFETY PROFILE OF KARISALAI KARPAM BY 28 DAYS REPEATED ORAL TOXICITY STUDY IN ANIMAL MODEL

G. Bharathkumar* and M. Pitchiah Kumar

Abstract

Karisalai Karpam is a hepato protective herb in its combination. In Bogar 7000 the Siddha literature this drug has been mentioned. The composition of Karisali Karpam (KK) as per the Siddha traditional preparation are Eclipta alba (Vellai Karisalai Samoolam), Wedelia chinensis (Manjal Karisalai samoolam), Indigofera tinctoria (Neeli Samoolam), Sphaeranthus indicus (Kottaikarandhai Samoolam), Centella asiatica (Vallarai Samoolam), Acalypha indica (Kuppeimeni) and Coldenia procumbens (Siruserupadai). KK has various medicinal properties. Herbal remedies are considered safer and less damaging to the human body than synthetic drugs. In India, about 80% of the rural population uses medicinal herbs or indigenous systems of medicine. The toxicity profile of Karisalai Karpam has not been addressed, hence it was taken for 28 days repeated oral toxicity study. It was carried out as per OECD guidelines. (Guideline - 407) Animals were divided into three groups of 6 animals each consist of 3 male and 3 female rats. The animals were administrated with the study drug once daily for 28 days. The animals in group I (control group) received normal saline 5 ml/kg b.w. The animals in group II received low dose of Karisalai Karpam200 mg/kg b.w(p.o) and group III received high dose of Karisalai Karpam 400 mg/kg b.w(p.o). The results of Sub-acute oral administration for 28 consecutive days of Karisalai Karpam (200 and 400 mg/kg, p.o) have shown no significant changes in the body weight, food intake, water intake general behavior, clinical signs as well as mortality of rats.

Keywords: Sub acute toxicity, Animal study, Siddha, Poly herbal medicine, Karisalai Karpam.


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