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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF IBUPROFEN BY UV SPECTROSCOPY

Kunal Shrikant Supe* and Jagruti Jagdish Patil

Abstract

Aim: Analytical Method Development and Validation of Ibuprofen by UV Spectroscopy. Objective: The objective of the present research work deals with simple, accurate, precise UV Spectroscopic method using Absorption Maxima Spectroscopy method for estimation of Ibuprofen in bulk and validated as per ICH guidelines. Method: The methods use methanol as a solvent for analysis. For the identification of drug, Solubility, FTIR, melting point studied. The wavelengths were determined for drug in the range of 200-400 nm in spectrum mode. UV-spectrophotometer-equipment used. The validity of the methods is established on the basis of linearity, accuracy and precision, limit of detection and Limit of quantification. The methods applied to estimate the level of Ibuprofen in a Tablet Dosage form. Results: In Absorption maxima method the linearity of the methods was in the range of (6 – 36) μg /ml at λ max 226 nm for Ibuprofen. The % RSD for all parameters were found within 2%. The result showed that the proposed method was suitable for the accurate, precise and rapid determination of Ibuprofen in its bulk and tablet dosage form. The method was validated as per ICH guidelines

Keywords: Ibuprofen, Absorption Maxima Method, UV- spectrophotometry, BRUFEN®.


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