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Abstract

DEVELOPMENT OF FORMULATIONS AND SYSTEMATICALLY EVALUATED IN-VITRO DIFFUSION OF BUCCAL PATCHES OF KETOROLAC

M. Sai Kumar, *H. Parameshwar and A. V. Jithan

Abstract

The objective of present study was to develop matrix type buccal patch therapeutic systems of Ketorolac using various hydrophilic and hydrophobic polymers as matrix formers. Results revealed that prepared patches showed good physical characteristics, no drugpolymer interaction was observed. The in vitro release study revealed that F1 formulation showed maximum release in 16 hrs. The release kinetics of formulation F1 followed Higuchi model. Formulation F1 was subjected for accelerated stability studies. The F1 formulation was found to be stable as there was no drastic change in the Physicochemical properties of the patchesF1, F2, F3, F4, F5, F6, F7 and F8 formulations showed highest cumulative percentage drug release of 98.38%, 97.92%, 99.10%, 97.32% were obtained during in vitro drug release studies after 16 hrs. The release of Ketorolac appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F1 formulation was concluded as optimized formulation.

Keywords: Buccal patch, Buccal delivery system, Ketorolac, Sodium aliginate & Eudragit, Diffusion mechanism.


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