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Abstract

ROLE OF MAINTAINING CAUSE AS IGE MEDIATED ANTIBODIES IN THE MANAGEMENT OF EOSINOPHILIC ESOPHAGITIS PRESENTING GERD - A SINGLE BLIND RANDOMIZED PLACEBO CONTROL TRIAL

Khatri P.*, Mathur G., Kansal S. and Mehrotra S.

Abstract

Objectives: To compare the pre and post treatment between two groups of eosinophilic esophagitis using GERD-Q questionnaire. To assess predominant miasm in cases of eosinophilic esophagitis with the aid of Hahnemann’s chronic disease. Study Design: Single blind, randomised, placebo control trial. Materials and Methodology: A total of 100 cases of Eosinophilic esophagitis were randomly allocated to the two treatment groups, Individualized Homeopathic Medicine group- Group A (n=50) and Placebo group- Group B (n=50). Potency selection, dosage and repetition of medicine of Group A were done according to patient’s susceptibility and homoeopathic principles. The outcome measures were lowering of GERD score in both groups after three months of treatment with removal of maintaining cause. Results: Observations and result show that among 100 cases of Eosinophilic esophagitis enrolled in the study: Patients treated with Individualized Homeopathic medicine selected on the basis of totality have significant improvement as compared to Placebo with removal of maintaining cause. The most frequently prescribed homoeopathic medicines in Group A were China (n=6), Arsenic (n=5), Nux Vom. (n=5), Phosphorus (n=4), Pulsatilla (n=4) and Lycopodium (n=4). Symptoms of heartburn, regurgitation, nausea, vomiting and sleep disturbances were highly improved. Among the 50 cases of Eosinophilic Esophagitis enrolled in Group A in which Individualized Homoeopathic Medicine was given with removal of maintaining cause showed marked improvement in 22 (44%) cases. Whereas among 50 cases of Eosinophilic esophagitis enrolled in Group B belonging to Placebo with removal of maintaining cause showed mild improvement in 28 (56%) cases by lowering the GERD Q score. The predominant miasm found in this study was mainly psora. Conclusion: From the study “Role Of Maintaining Cause As IgE Mediated Antibodies in The Management of Eosinophilic Esophagitis Presenting GERD - A Single Blind Randomized Placebo Control Trial” it is evident that removing of maintaining cause along with Individualized Homoeopathic medicine is a useful approach in cases of Eosinophilic Esophagitis presenting GERD as compared to only removal of maintaining cause. There were significant changes in GERD Q in Medicinal group. The most commonly indicated medicine are China, Nux vom., Arsenic, Phosphorus, Pulsatilla, Lycopodium. From this study it can be concluded that Psora is the predominant miasm lying in the background of the patients suffering from Eosinophilic esophagitis.

Keywords: Eosinophilic esophagitis, Individualised Homoeopathic Medicine, Placebo, GERD, SPT.


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