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Abstract

SYNTHESIS, STRUCTURAL ANALYSIS, & ANTIMICROBIAL EVALUATION OF ANILIDE, & THEIR DERIVATIVES OF AROMATIC ALDEHYDE

Astitva Agarwal*, Aarohi Ahuja*, Abhishek Shandilya and Anil Kumar Koshal

Abstract

This work presents the tailoring, characterization, and biological applications of anilide derivatives with aromatic aldehydes. Anilides are an important class of industrially organic compounds with diverse pharmacological activities such as antibacterial, anthelmintic, antifungal, Anti-inflammatory and many more. The potential of biological activity of anilide is enhanced with increasing heteroatom in the compound. These biological activities are showed more potential with having semi-carbazone moiety. TLC monitors the reaction's progress and competition of reaction. The structures of the synthesised compounds were analysed using spectral data from IR and 1H-NMR, which revealed the expected frequencies and signals. The synthesized compounds (2a-2e) were investigated for anti-biological activity by agar well diffusion method. Compound [2c] showed excellent activity while compound [2e] exhibited moderate activity against Staphylococcus aureus bacterial stains.

Keywords: Anilide, Azomethine moiety, IR, 1H-NMR, Antimicrobial Evaluation.


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